Eighth Call Awards

Low Cost Companion Diagnostic Test for Predicting Benefit of Adjuvant Chemotherapy in ER+ Breast Cancer

Vani Parmar

Tata Memorial Centre, Mumbai

vaniparmar@gmail.com
Anant Madabhushi

Case Western Reserve University, Cleveland

anant.madabhushi@case.edu
The Problem:
There has been a dramatic increase in breast cancer incidence over the last decade, which has led to an increased demand for predictive and prognostic companion diagnostic (CDx) assays to ascertain the aggressiveness of cancer phenotypes so that patients with less aggressive biology can be spared chemotherapy.
The Solution:
Predictive CDx assays can aid in design of clinical trials, and help reduce healthcare costs by optimizing treatment regimens. This project proposes an accurate and low-cost prognostic test based solely on digitized Hematoxylin and Eosin (H&E) tissue slides for identifying which Indian women with Estrogen Receptor positive (ER+) breast cancers will receive additional benefit from adjuvant chemotherapy. The technology (image-based risk score; IbRiS) uses computerized image analysis algorithms and needs digitally scanned tissue slide images.

Blood Test for All Forms of Active Tuberculosis (TB) for Commercialization in India Principal Investigators

Sarman Singh

All India Institute of Medical Sciences, Bhopal

sarman.singh@gmail.com
Vivek Chandra

NextGen Invitro Diagnostics Pvt. Ltd. Gurugram

vivek.chandra@ngivd.com
Imran Khan

University of California, Davis, Sacramento

ihkhan@ucdavis.edu
The Problem:

According to a WHO Report in 2016, India ranks at the top among the tuberculosis (TB) endemic countries because TB case detection is inadequate and there are no good diagnostics available for pulmonary, extra-pulmonary and pediatric TB.

The Solution:
This project proposes the development of a multiplex blood-based test (RU-1) for the detection of all forms of TB. The test is cost-effective and can be used on dried blood spots (ensures easy collection in remote areas); displays 91% - 96% specificity; is instrument agnostic and runs on multiple systems. It is suitable for high-burden settings and provides quick turnaround of results when patient loads are high.

VECTRAX, an Efficacious Long Lasting Semiochemical Based Attract and Kill Formulation for Management of Mosquito Vectors of Human Diseases Principal Investigators

Markandeya Gorantla

ATGC Biotech Pvt. Ltd., Secunderabad

mg@atgc.in
Agenor Mafra-Neto

ISCA Technologies, Riverside

president@iscatech.com
The Problem:

Lack of effective and optimized monitoring and control strategy for vector and mosquitoes in urban and rural environments.

The Solution:

The proposal aims at commercializing a unique, efficacious and long-lasting semiochemical-based attract and kill (A&K) formulation to control Dengue, Zika, Malaria, Chikungunya and Filariasis Mosquito Vectors. The product Vectrax, is a patented floral attractant and phagostimulant blend of sugars and proteins with lethal doses of insecticide that lures the mosquito to feed continuously until it is fully engorged. Vectrax is a slow-release, sprayable formulation, that can be used through micro and macro bait stations and can sustain its A&K capacity in the field for weeks at a time.

Test4Safety: Detection of Adulteration in commonly consumed liquids

Deepa Bhajekar

D Technology Pvt. Ltd., Mumbai

drdeepa@dtechnology.ooo
Deepak Mehrotra

Data Analytics Company, Agoura Hills

deepak@oakanalytics.com
The Problem:

Monitoring of the food supply to test for adulterated or fake products is limited both by lack of financial resources and availability of test procedures that can quickly confirm the authenticity of a product as it is delivered to the end consumer.

The Solution:

A method for quick detection of food adulteration, the technology involves a handheld pocket scanner that transmits a low-power laser beam into the test sample. The captured Raman response is compared to the “golden signature” in a cloud-based database. The user gets instant verification on their phones if the food product is genuine.

Precise Fertilizer Applicator (international patents filed) for Doubling Farmers' Profits and Reducing Environmental Damage including Soil, GHG & Water

Ayush Nigam

Distinct Horizon Pvt. Ltd., Hyderabad

ayushnigam2@gmail.com
Shalu Umapathy

IDEO.org, San Francisco

shalu@ideo.org
The Problem:

The current method of fertilizer application results in up to 70% wastage, which drastically degrades the soil, pollutes water and yet does not improve productivity.

The Solution:

This project proposes precision application of fertilizer through a powered Urea Deep Placement (UDP) applicator that is integrated with soil testing. The technology envisages 25% increase in yields; 40% reduction in fertilizer consumption; 7-8 times reduction in labour requirement; doubling of farmers' profits; and increasing soil organic content.